Search results for " Ventilator-Associated"

showing 3 items of 3 documents

Mechanical ventilation alters the development of staphylococcus aureus pneumonia in rabbit

2016

Ventilator-associated pneumonia (VAP) is common during mechanical ventilation (MV). Beside obvious deleterious effects on muco-ciliary clearance, MV could adversely shift the host immune response towards a pro-inflammatory pattern through toll-like receptor (TLRs) up-regulation. We tested this hypothesis in a rabbit model of Staphylococcus aureus VAP. Pneumonia was caused by airway challenge with S. aureus, in either spontaneously breathing (SB) or MV rabbits (n = 13 and 17, respectively). Pneumonia assessment regarding pulmonary and systemic bacterial burden, as well as inflammatory response was done 8 and 24 hours after S. aureus challenge. In addition, ex vivo stimulations of whole blood…

0301 basic medicinePulmonologyPhysiologyStaphylococcusmedicine.medical_treatment[SDV]Life Sciences [q-bio]lcsh:MedicinePharmacologyPathology and Laboratory Medicinemedicine.disease_causeStaphylococcal/immunology/pathologyImmune ReceptorsBiochemistry0302 clinical medicineImmune PhysiologyPneumonia StaphylococcalMedicine and Health SciencesMedicineStaphylococcus Aureuslcsh:ScienceImmune ResponseToll-like ReceptorsMammalsddc:616Innate Immune SystemImmune System ProteinsMultidisciplinaryddc:617RespirationPneumonia Ventilator-AssociatedInterleukinAnimal ModelsHematologyBacterial PathogensBody Fluids3. Good healthBloodmedicine.anatomical_structureMedical MicrobiologyStaphylococcus aureusVertebratesArtificialCytokinesRabbitsPathogensAnatomymedicine.symptomStaphylococcus aureus/immunologyResearch ArticleSignal TransductionToll-Like Receptor 2/immunologyImmunologyInflammationLung injuryResearch and Analysis MethodsMicrobiology03 medical and health sciencesModel OrganismsSigns and SymptomsDiagnostic MedicineAnimalsMicrobial PathogensInflammationMechanical ventilationInterleukin-8/immunologyLung[ SDV ] Life Sciences [q-bio]BacteriaTumor Necrosis Factor-alphabusiness.industrylcsh:RInterleukin-8OrganismsBiology and Life SciencesProteins030208 emergency & critical care medicineCell BiologyPneumoniaMolecular Developmentmedicine.diseaseTumor Necrosis Factor-alpha/immunologyRespiration ArtificialToll-Like Receptor 2Pneumonia030104 developmental biologyVentilator-Associated/immunology/microbiology/pathologyImmune SystemAmniotesImmunologylcsh:QbusinessSpleenEx vivoDevelopmental Biology
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Healthcare-Associated Pneumonia and Multidrug Resistant Bacteria: Do We Have a Convincing Answer?

2014

Methicillin-Resistant Staphylococcus aureusMicrobiology (medical)medicine.medical_specialtyBacteriabusiness.industryMedicine (all)Drug ResistanceBacterialPneumonia Ventilator-AssociatedBacteria; Enterobacteriaceae; Humans; Methicillin-Resistant Staphylococcus aureus; Pneumonia Ventilator-Associated; Pseudomonas aeruginosa; Drug Resistance Bacterial; Infectious Diseases; Microbiology (medical); Medicine (all)Pneumoniamedicine.diseasePneumoniaVentilator-AssociatedMultidrug resistant bacteriaInfectious DiseasesHealthcare associatedEnterobacteriaceaeDrug Resistance BacterialPseudomonas aeruginosamedicineBacteria; Enterobacteriaceae; Humans; Methicillin-Resistant Staphylococcus aureus; Pneumonia; Ventilator-Associated; Pseudomonas aeruginosa; Drug Resistance; Bacterial; Infectious Diseases; Microbiology (medical); Medicine (all)HumansIntensive care medicinebusiness
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Inhaled amikacin versus placebo to prevent ventilator-associated pneumonia: the AMIKINHAL double-blind multicentre randomised controlled trial protoc…

2021

IntroductionPre-emptive inhaled antibiotics may be effective to reduce the occurrence of ventilator-associated pneumonia among critically ill patients. Meta-analysis of small sample size trials showed a favourable signal. Inhaled antibiotics are associated with a reduced emergence of antibiotic resistant bacteria. The aim of this trial is to evaluate the benefit of a 3-day course of inhaled antibiotics among patients undergoing invasive mechanical ventilation for more than 3 days on the occurrence of ventilator-associated pneumonia.Methods and analysisAcademic, investigator-initiated, parallel two group arms, double-blind, multicentre superiority randomised controlled trial. Patients invasi…

medicine.medical_specialtymedicine.medical_treatmentinfectious diseasesPlacebolaw.inventionrespiratory infections03 medical and health sciences0302 clinical medicineDouble-Blind MethodRandomized controlled trialInformed consentlawAdministration InhalationmedicineHumansMulticenter Studies as Topic1506Amikacinadult intensive & critical care1707Randomized Controlled Trials as TopicMechanical ventilationclinical trials[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologybusiness.industryIntensive CareRVentilator-associated pneumoniaPneumonia Ventilator-Associated030208 emergency & critical care medicineGeneral Medicinemedicine.diseaseRespiration Artificial3. Good healthClinical trialPneumoniaTreatment Outcome030228 respiratory systemAmikacinEmergency medicineMedicinebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologymedicine.drugBMJ Open
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